KPV

Anti-inflammatory C-terminal tripeptide of α-MSH.

Overview

KPV (Lys-Pro-Val) is the C-terminal tripeptide of α-MSH and retains much of α-MSH's anti-inflammatory activity without pigmentary effects. Preclinical work in colitis and skin inflammation models.

Mechanism

NF-κB pathway inhibition; reduction of pro-inflammatory cytokines.

Research areas

IBD models
Atopic dermatitis
Oral inflammation

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