# Thymogen

> A synthetic thymic dipeptide (Glu-Trp) immunomodulator — the minimal active fragment distilled from thymus peptides.

- Also known as: Glutamyl-Tryptophan, Glu-Trp dipeptide, Bestim
- Class: Immune, Bioregulators
- FDA approved: No
- Canonical page: https://americanpeptide.com/catalog/thymogen

## Overview

Thymogen is a synthetic dipeptide, glutamyl-tryptophan (Glu-Trp), developed in the Russian bioregulator tradition as a minimal, defined immunomodulator. It is essentially the shortest active core distilled from thymic peptide preparations like Thymalin — a two-amino-acid sequence studied for restoring and balancing immune function. It has been used in Russia, given intranasally or by injection, as an immunostimulant during infection and recovery.

Thymogen is the dipeptide endpoint of a long reductionist thread in Russian peptide research: starting from whole thymus extracts (Thymalin), then isolating ever-shorter active fragments, investigators arrived at glutamyl-tryptophan — just two residues — as a sequence that still carried immunomodulatory activity. That makes it a companion to the other thymic peptides in this catalog: Thymalin (the extract) and thymosin α-1 (a 28-residue thymic peptide), with Thymogen as the minimal synthetic core.

It has been used clinically in Russia as an immunostimulant — given intranasally or by injection to support immune function during infections and convalescence — though, like the rest of the bioregulator tradition, its evidence base is concentrated there with limited independent Western trials. It is a research compound and is not FDA-approved.

## Mechanism

Immunomodulatory (bioregulator) activity — proposed to normalize T-cell and broader immune-cell function, in the same thymic-peptide tradition as Thymalin and thymosin α-1.

## Chemistry

| Property | Value |
| --- | --- |
| Molecular formula | C16H19N3O5 |
| Molecular weight | 333.34 Da |

## Sequence

```
Glu-Trp
```

## Research areas

Studied in: Immune modulation, Infection recovery, Peptide bioregulators.

Guides on this site:

- [Immune & Inflammation](https://americanpeptide.com/research-areas/immune-inflammation): Thymic and host-defense peptides studied for immune modulation.
- [Peptide Bioregulators](https://americanpeptide.com/research-areas/bioregulators): Short, tissue-specific peptides proposed to regulate gene expression — the Khavinson series.

## Key research

- Minimal thymic peptide — glutamyl-tryptophan (Glu-Trp), the shortest active immunomodulatory core distilled from thymic peptide preparations.
- Immune modulation — studied for normalizing T-cell and immune-cell function, in the thymic-peptide tradition of Thymalin and thymosin α-1.
- Clinical use (Russia) — used as an intranasal or injectable immunostimulant for infection and recovery support.
- A defined dipeptide — unlike the Thymalin extract, a single two-residue synthetic sequence.
- Evidence quality — concentrated in one research tradition; not FDA-approved.

## Storage, handling & synthesis

**Synthesis.** Thymogen (glutamyl-tryptophan) is a dipeptide — one of the simplest defined immunopeptides — made trivially by solution or solid-phase synthesis. Protecting the oxidation-sensitive tryptophan and controlling the counterion are the only real considerations; there is essentially no synthetic difficulty.

## FAQs

### What is Thymogen?

Thymogen is a synthetic dipeptide (glutamyl-tryptophan) immunomodulator — the minimal active core distilled from thymic peptides, studied for balancing immune function.

### How does it relate to Thymalin?

Thymalin is the whole thymus peptide extract; Thymogen is the shortest active synthetic fragment (two amino acids) derived from that tradition.

### What is it used for?

It has been used in Russia as an intranasal or injectable immunostimulant during infections and recovery; its evidence base is concentrated in that research tradition.

### Is Thymogen approved?

No — it is a research compound, not FDA-approved. This page is a research and educational reference.

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Source: AmericanPeptide.com — https://americanpeptide.com/catalog/thymogen
Data license: CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/). Attribution: AmericanPeptide.com.
Research reference only — computational and educational content, not medical advice.