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PEGylation

American Peptide Company, Inc. makes the case for slightly increasing the cost-of-goods of peptide APIs by chemical modification with PEG as a cost-effective trade-off for a potential increase in bioavailability over the injected naked peptide.

PEGylation is an FDA-approved delivery system for peptide and protein-based biopharmaceuticals. The process of specific PEGyaltion involves the chemical attachment of polyethylene glycol (PEG) to a therapeutic peptide or protein at a specific site on the molecule. Your API can have significantly improved therapeutic properties, including better patient compliance and side effect profile.